Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma
نویسندگان
چکیده
منابع مشابه
Optic Nerve Head Blood Flow in Glaucoma
These days it is commonly accepted that multiple factors are involved in the etiology of glaucoma. Although many studies have demonstrated that the major risk factor for glaucoma is an increase in intraocular pressure (IOP), some studies, including epidemiologic studies, have suggested an association between glaucoma, especially primary open-angle glaucoma (POAG) and normal-tension glaucoma (NT...
متن کاملThe optic nerve head in myocilin glaucoma.
PURPOSE Approximately 1 in 30 unselected patients with open-angle glaucoma (OAG) have a mutation in the myocilin gene. The purpose of this study was to describe the morphologic features of the optic nerve head (ONH) in myocilin glaucoma. METHODS A case-control design was adopted. Sixty-six patients heterozygous for a range of myocilin mutation (cases) were matched in disease severity to 105 p...
متن کاملThe optic nerve head in glaucoma
The ONH can be examined using a direct ophthalmoscope, an indirect ophthalmoscope, or a posterior pole lens with a slit lamp. Many types of health professional can assess the ONH accurately after having appropriate training. Dilating the pupil makes this easier and will improve the accuracy of the examination, regardless of which instrument is used. Where the equipment is available, more sophis...
متن کاملOptic nerve head drusen and glaucoma.
The simultaneous occurrence of both optic nerve head drusen and glaucoma may make it difficult to evaluate visual field defects and the appearance of the optic nerve head. We saw five patients with both conditions, of whom four had pigmentary glaucoma or pigmentary dispersion syndrome. Drusen do not preclude the development of cupping, and they make it difficult to interpret its significance. M...
متن کاملMicroglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma.
BACKGROUND Microglia, the macrophages and immune surveillance cells of the central nervous system, are quiescent normally but become activated in injured neural tissue. We have determined the distribution and potential participation of microglia in glaucomatous optic nerve degeneration. METHODS Microglia were localized by immunohistochemistry on paraffin sections of age-matched normal and gla...
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ژورنال
عنوان ژورنال: Molecular Neurobiology
سال: 2020
ISSN: 0893-7648,1559-1182
DOI: 10.1007/s12035-020-01910-9